Winterhalter S, Ruokonen P, van der Velden K H, Pleyer U, Joussen A M
Universitätsaugenklinik Charité, Virchow- Klinikum, Augustenburger Platz 1, 13353, Berlin, Deutschland.
Ophthalmologe. 2011 Mar;108(3):222-9. doi: 10.1007/s00347-010-2264-y.
Immunosuppressive agents are used for the therapy of noninfectious uveitis if intraocular quiescence and freedom from recurrences are not achievable with oral steroids at a low dosage. Partially, severe side effects are tolerated to preserve visual acuity even if the disease is limited to the eyes. Because of this a therapy would be desirable which is highly effective, limited to the eyes and with few side effects. For this fluocinolone acetonide and dexamethasone drug delivery systems were developed. Dexamethasone implants were already approved for the therapy of retinal vein occlusions and are used successfully. Diabetic macular edema would be another possible indication for dexamethasone implants.
如果低剂量口服类固醇无法实现眼内静止且无复发,免疫抑制剂可用于非感染性葡萄膜炎的治疗。即使疾病仅局限于眼部,为了保留视力,也会部分耐受严重的副作用。因此,一种高效、仅限于眼部且副作用少的治疗方法将是理想的。为此,开发了醋酸氟轻松和地塞米松药物递送系统。地塞米松植入物已被批准用于治疗视网膜静脉阻塞并取得了成功。糖尿病性黄斑水肿可能是地塞米松植入物的另一个潜在适应症。