Department of Oral Anatomy and Physiology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.
J Neurosci Res. 2011 Jun;89(6):802-7. doi: 10.1002/jnr.22613. Epub 2011 Mar 21.
Carbon monoxide (CO) has been recognized to act as an atypical neurotransmitter or neuromodulator in the nervous system and to be involved in a wide variety of neuronal activities. Several lines of evidence suggest that CO may play a role through multiple mechanisms in nociception processing. Differential regulation of a family of CO-generating enzymes, heme oxygenase (HO), contributes mainly to the complexity underlying the role of CO in nociception. This Mini-Review describes the latest evidence for the role of CO during normal sensory transmission and pathological pain conditions and discusses potential cellular mechanisms by which CO is involved in pathological pain.
一氧化碳（CO）已被确认为神经系统中的一种非典型神经递质或神经调质，并参与多种神经元活动。有几条证据表明，CO 可能通过多种机制在伤害感受处理中发挥作用。一组产生 CO 的酶，血红素加氧酶（HO）的差异调节，主要有助于解释 CO 在伤害感受中作用的复杂性。这篇综述描述了 CO 在正常感觉传递和病理性疼痛状态下的作用的最新证据，并讨论了 CO 参与病理性疼痛的潜在细胞机制。
