Department of Chemistry and Biochemistry, University of California, Santa Cruz, 95064, USA.
Future Med Chem. 2009 Nov;1(8):1497-507. doi: 10.4155/fmc.09.111.
The discovery of various regulatory, protective and deleterious effects of nitric oxide (NO) has prompted intense research activity in the design and synthesis of NO-donating drugs and materials that can be used to modulate the effective concentrations of NO at biological targets. To date, various NO-donating compounds have been incorporated or immobilized in biocompatible polymer matrices and such materials have been used as patches, wound dressings, coatings on blood-contacting medical devices and time-release NO drugs. Recently, attention has been drawn toward light-sensitive NO donors, such as S-nitrosothiols and metal nitrosyls, which can deliver NO at selected targets under the total control of light. The pharmacological potential of such NO-donating materials including those with immobilized photoactive NO donors are reviewed in this article.
一氧化氮（NO）的各种调节、保护和有害作用的发现，促使人们积极设计和合成能调节生物靶标中有效 NO 浓度的供氮药物和材料。迄今为止，各种供氮化合物已被掺入或固定在生物相容性聚合物基质中，并且这些材料已被用作贴剂、伤口敷料、与血液接触的医疗设备的涂层和控释 NO 药物。最近，人们对光敏感的 NO 供体（如 S-亚硝基硫醇和金属亚硝酰）产生了兴趣，这些供体可以在光的完全控制下，在选定的靶标处输送 NO。本文综述了这些具有固定光活性 NO 供体的供氮材料的药理学潜力。
