17β-雌二醇和孕酮均可独立增强皮肤热充血，但不增强反应性充血。
17β-estradiol and progesterone independently augment cutaneous thermal hyperemia but not reactive hyperemia.
机构信息
Department of Human Physiology, University of Oregon, Eugene, Oregon, USA.
出版信息
Microcirculation. 2011 Jul;18(5):347-55. doi: 10.1111/j.1549-8719.2011.00095.x.
OBJECTIVE
We examined the impact of estradiol and progesterone on skin LH and RH in 25 healthy women.
METHODS
Subjects were studied three times over 10-12 days. Endogenous sex hormones were suppressed with a GnRHa. Subjects were studied on day 4 of suppression (study day 1), three to four days later following treatment with either 17β-estradiol or progesterone (study day 2), and another three to four days later, following treatment with both estradiol and progesterone (study day 3). Subjects underwent identical LH and RH protocols on all study days. LH is characterized by an initial peak in blood flow, followed by a prolonged plateau. A brief nadir is seen between the phases.
RESULTS
Blood flow values are expressed as percent maximum CVC. Estradiol alone increased initial peak CVC from 71 ± 2% to 79 ± 2% (p = 0.001). Progesterone alone increased initial peak CVC from 72 ± 2% to 78 ± 2% (p = 0.046). Neither estradiol nor progesterone increased plateau CVC. No significant changes were seen between study days 2 and 3 for either group. No differences were observed in RH.
CONCLUSIONS
Both estradiol and progesterone increased initial peak CVC during LH, without altering plateau CVC. There was no additive effect of estradiol and progesterone.
目的
我们研究了雌二醇和孕酮对 25 名健康女性皮肤 LH 和 RH 的影响。
方法
研究对象在 10-12 天内接受了三次检查。通过 GnRHa 抑制内源性性激素。在抑制的第 4 天（研究第 1 天）、治疗后 3-4 天（研究第 2 天）给予 17β-雌二醇或孕酮、以及治疗后 3-4 天（研究第 3 天）给予雌二醇和孕酮后，对受试者进行了研究。所有研究日，受试者均接受相同的 LH 和 RH 方案。LH 的特征是血流初始峰值，随后是长时间的平台期。两个阶段之间可见短暂的低谷。
结果
血流值表示为最大 CVC 的百分比。仅雌二醇就将初始峰值 CVC 从 71 ± 2%增加到 79 ± 2%（p = 0.001）。仅孕酮就将初始峰值 CVC 从 72 ± 2%增加到 78 ± 2%（p = 0.046）。雌二醇和孕酮均未增加平台期 CVC。两组在研究第 2 天和第 3 天之间均未发生显著变化。RH 无差异。
结论
雌二醇和孕酮均增加 LH 期间的初始峰值 CVC，而不改变平台期 CVC。雌二醇和孕酮没有叠加效应。
Zotero 插件