Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, USA.
Cancer J. 2011 Mar-Apr;17(2):89-95. doi: 10.1097/PPO.0b013e318212dd3d.
Chemotherapy treatments are considered essential tools to defeat cancer progression and dissemination to improve patients' quality of life and survival. Although most malignancies initially respond to chemotherapeutic treatments, after an unpredictable period, tumor cells develop mechanisms of resistance to the treatment. Different cell compartments are involved in the mechanism of chemoresistance, and multiple mechanisms can be activated by single cells at different times of the cancer progression. Alteration of drug metabolism, derangement of intracellular pathways' signaling, cross-talk between different membrane receptors, and modification of apoptotic signaling and interference with cell replication are all mechanisms that the cell uses to overcome the effect of pharmacological compounds.In this review, we describe different adaptation, mostly at the level of the proteome, which cancer cells use to develop resistance to cancer treatment.
化疗被认为是战胜癌症进展和扩散的重要手段，可改善患者的生活质量和延长生存期。尽管大多数恶性肿瘤最初对化疗有反应，但在不可预测的一段时间后，肿瘤细胞会产生对治疗的耐药机制。不同的细胞区室参与了耐药机制，并且单个细胞在癌症进展的不同时间可以激活多种机制。药物代谢的改变、细胞内信号通路的紊乱、不同膜受体之间的串扰以及凋亡信号的修饰和对细胞复制的干扰，都是细胞用来克服药理化合物作用的机制。在这篇综述中，我们描述了癌细胞用于对癌症治疗产生耐药性的不同适应，主要是在蛋白质组水平上。
