Dittrichová J, Paul K, Pavlíková E
Early Hum Dev. 1977 Dec;1(3):213-25. doi: 10.1016/0378-3782(77)90036-6.
11 healthy children were repeatedly studied during 2 sleep cycles in 2 sessions at 2,6, 12 and 20 wk of life. Three acoustic stimuli, light and tactile stimulus were applied in a randomized order in intervals ranging randomly from 30 to 120 sec. Continuous polygraphic recordings were made of respiration, REMs, EEG and EMG of biceps and triceps brachii. The effect of stimuli on the length of paradoxical sleep, REMs and EMG was assessed. There were age-related changes in the number of REMs after stimuli. At 2 and 6 wk no stimulus elicited any change. At 12 wk the children responded with an increased number of rapid eye movements to acoustic stimuli, at 20 wk they responded to acoustic stimuli and light. The conclusion is that, as far as REMs are concerned, responsiveness during paradoxical sleep changes with age. There was a difference in the incidence of EOG responses and EMG responses. These findings show that it is not possible to assess responsiveness in infants during PS by one measure only.
11名健康儿童在出生后2周、6周、12周和20周时，分两个阶段，在两个睡眠周期内接受了反复研究。三种听觉刺激、光刺激和触觉刺激以随机顺序施加，间隔时间随机在30至120秒之间。对呼吸、快速眼动、脑电图以及肱二头肌和肱三头肌的肌电图进行了连续的多导记录。评估了刺激对异相睡眠时长、快速眼动和肌电图的影响。刺激后快速眼动的数量存在与年龄相关的变化。在2周和6周时，没有刺激引发任何变化。在12周时，儿童对听觉刺激的快速眼动数量增加，在20周时，他们对听觉刺激和光刺激都有反应。结论是，就快速眼动而言，异相睡眠期间的反应性随年龄而变化。眼电图反应和肌电图反应的发生率存在差异。这些发现表明，仅通过一种测量方法无法评估婴儿在异相睡眠期间的反应性。
