探索老药治疗血液系统恶性肿瘤。

Exploring old drugs for the treatment of hematological malignancies.

机构信息

Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou, China.

出版信息

Curr Med Chem. 2011;18(10):1509-14. doi: 10.2174/092986711795328427.

DOI:10.2174/092986711795328427

PMID:21428892

Abstract

Drug discovery is costly and time-consuming, but it will become easier and simpler if a drug could be developed from an old one with well-documented investigations associated with pharmacology, pharmacokinetics, toxicology and clinical safety. In terms of hematological malignancies, several successful drugs have been discovered and developed from old ones such as arsenic trioxide for acute promyelocytic leukemia and thalidomide for multiple myeloma. In this review, we discussed the latest advancement in exploring old drugs for the treatment of hematological malignancies.

摘要

药物研发既昂贵又耗时，但如果一种药物可以在具有充分药理学、药代动力学、毒理学和临床安全性研究的旧药基础上开发，那么药物研发将会变得更容易和简单。在血液系统恶性肿瘤方面，已经有几种成功的药物从旧药中被发现和开发出来，如三氧化二砷治疗急性早幼粒细胞白血病和沙利度胺治疗多发性骨髓瘤。在这篇综述中，我们讨论了探索旧药治疗血液系统恶性肿瘤的最新进展。