Berbis P, Hesse S, Privat Y
Clinique Dermatologique, Hôtel Dieu, Marseille.
Allerg Immunol (Paris). 1990 Jun;22(6):225-31.
Metabolism of the essential fatty acids (AGE) in an organism leads to synthesis of eicosanoids, which have various biological properties. Linoleic acid plays an important part in maintenance of epidermal integrity by intervening in the cohesion of the stratum corneum and in prevention of transepidermal water loss. Metabolites of arachidonic acid (mostly those obtained by the lipoxygenase pathway) are important agents in causing many inflammatory skin reactions concurrent with development of skin diseases such as psoriasis and atopic dermatitis. Pharmacological and dietetic control of the metabolism of arachidonic acid is a new and interesting therapeutic concept in the care of skin diseases. Also, fish oil, which is rich in linoleic acid and poor in arachidonic acid, seems to be useful in basal treatment of psoriasis. The value of evening primrose oil, which is rich in gamma-linoleic acid, in the treatment of atopic dermatitis is discussed.
生物体中必需脂肪酸（AGE）的代谢会导致类花生酸的合成，类花生酸具有多种生物学特性。亚油酸通过干预角质层的黏附以及预防经皮水分流失，在维持表皮完整性方面发挥着重要作用。花生四烯酸的代谢产物（主要是通过脂氧合酶途径获得的那些产物）是引发许多炎症性皮肤反应的重要介质，这些反应与诸如牛皮癣和特应性皮炎等皮肤病的发展同时发生。对花生四烯酸代谢进行药理和饮食控制是皮肤病护理中一个新的且有趣的治疗理念。此外，富含亚油酸且花生四烯酸含量低的鱼油似乎对牛皮癣的基础治疗有用。文中讨论了富含γ-亚麻酸的月见草油在治疗特应性皮炎方面的价值。
