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Distinct roles for the cellular inhibitors of apoptosis proteins 1 and 2.

作者信息

Graber T E, Holcik M

机构信息

Apoptosis Research Centre, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON K1H8L1, Canada.

出版信息

Cell Death Dis. 2011 Mar 24;2(3):e135. doi: 10.1038/cddis.2011.20.

Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e48/3101816/532e9aef5dc5/cddis201120f1.jpg

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cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production.
Cell Death Differ. 2011 Apr;18(4):656-65. doi: 10.1038/cdd.2010.138. Epub 2010 Nov 5.
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NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response.
Cell Death Differ. 2010 Apr;17(4):719-29. doi: 10.1038/cdd.2009.164. Epub 2009 Nov 6.
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Down-regulation of c-FLIP Enhances death of cancer cells by smac mimetic compound.
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hnRNP A1 regulates UV-induced NF-kappaB signalling through destabilization of cIAP1 mRNA.
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Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation.
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