存活素——颇具争议的凋亡抑制蛋白
Survivin - The inconvenient IAP.
作者信息
Altieri Dario C
机构信息
Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
出版信息
Semin Cell Dev Biol. 2015 Mar;39:91-6. doi: 10.1016/j.semcdb.2014.12.007. Epub 2015 Jan 12.
Abstract
Although technically a member of the Inhibitor of Apoptosis (IAP) gene family, survivin has consistently defied assumptions, refuted predictions and challenged paradigms. Despite its more than 5500 citations currently in Medline, the biology of survivin has remained fascinatingly complex, its exploitation in human disease, most notably cancer, tantalizing, and its regulation of cellular homeostasis unexpectedly far-reaching. An inconvenient outsider that resists schemes and dogmas, survivin continues to hold great promise to unlock fundamental circuitries of cellular functions in health and disease.
摘要
尽管从技术上讲，生存素是凋亡抑制蛋白（IAP）基因家族的一员，但它一直违背各种假设、推翻预测并挑战范式。尽管目前在医学文献数据库（Medline）中其被引用次数超过5500次，但生存素的生物学特性仍然极其复杂，它在人类疾病（尤其是癌症）中的应用前景诱人，并且其对细胞稳态的调节作用出人意料地广泛。作为一个抗拒既定模式和教条的不合时宜的局外人，生存素仍极有可能揭示健康和疾病状态下细胞功能的基本机制。
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本文引用的文献
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Clinical aspects for survivin: a crucial molecule for targeting drug-resistant cancers.生存素的临床方面：靶向耐药性癌症的关键分子。
Drug Discov Today. 2015 May;20(5):578-87. doi: 10.1016/j.drudis.2014.11.013. Epub 2014 Nov 26.
2
Adhesion molecule-mediated hippo pathway modulates hemangioendothelioma cell behavior.黏附分子介导的 Hippo 通路调节血管内皮细胞瘤细胞行为。
Mol Cell Biol. 2014 Dec;34(24):4485-99. doi: 10.1128/MCB.00671-14. Epub 2014 Sep 29.
3
Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma.生存素作为音猬因子驱动的髓母细胞瘤的治疗靶点。
Oncogene. 2015 Jul;34(29):3770-9. doi: 10.1038/onc.2014.304. Epub 2014 Sep 22.
4
The impact of survivin on prognosis and clinicopathology of glioma patients: a systematic meta-analysis.生存素对胶质瘤患者预后及临床病理特征的影响：一项系统的Meta分析
Mol Neurobiol. 2015;51(3):1462-7. doi: 10.1007/s12035-014-8823-5. Epub 2014 Jul 27.
5
Prognostic significance of survivin in breast cancer: meta-analysis.生存素在乳腺癌中的预后意义：荟萃分析
Breast J. 2014 Sep-Oct;20(5):514-24. doi: 10.1111/tbj.12303. Epub 2014 Jul 8.
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Survivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1.生存素调节具有不同分子功能的基因，并通过Evi-1调节造血干细胞的增殖。
Leukemia. 2015 Feb;29(2):433-40. doi: 10.1038/leu.2014.183. Epub 2014 Jun 6.
7
microRNA-mediated survivin control of pluripotency.微小RNA介导的多能性的生存素调控
J Cell Physiol. 2015 Jan;230(1):63-70. doi: 10.1002/jcp.24681.
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10
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Br J Cancer. 2014 Jun 10;110(12):2935-44. doi: 10.1038/bjc.2014.226. Epub 2014 May 1.
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