Department of Neurology, Washington University in St. Louis, 660 South Euclid Ave, Box 08111, St. Louis, MO 63110, USA.
J Neuroimmune Pharmacol. 2011 Sep;6(3):409-19. doi: 10.1007/s11481-011-9270-y. Epub 2011 Mar 24.
Human immunodeficiency virus (HIV) and methamphetamine (METH) dependence are independently associated with neuronal dysfunction. The coupling between cerebral blood flow (CBF) and neuronal activity is the basis of many task-based functional neuroimaging techniques. We examined the interaction between HIV infection and a previous history of METH dependence on CBF within the lenticular nuclei (LN). Twenty-four HIV-/METH-, eight HIV-/METH+, 24 HIV+/METH-, and 15 HIV+/METH+ participants performed a finger tapping paradigm. A multiple regression analysis of covariance assessed associations and two-way interactions between CBF and HIV serostatus and/or previous history of METH dependence. HIV+ individuals had a trend towards a lower baseline CBF (-10%, p = 0.07) and greater CBF changes for the functional task (+32%, p = 0.01) than HIV- subjects. Individuals with a previous history of METH dependence had a lower baseline CBF (-16%, p = 0.007) and greater CBF changes for a functional task (+33%, p = 0.02). However, no interaction existed between HIV serostatus and previous history of METH dependence for either baseline CBF (p = 0.53) or CBF changes for a functional task (p = 0.10). In addition, CBF and volume in the LN were not correlated. A possible additive relationship could exist between HIV infection and a history of METH dependence on CBF with a previous history of METH dependence having a larger contribution. Abnormalities in CBF could serve as a surrogate measure for assessing the chronic effects of HIV and previous METH dependence on brain function.
人类免疫缺陷病毒 (HIV) 和甲基苯丙胺 (METH) 依赖与神经元功能障碍独立相关。脑血流 (CBF) 和神经元活动之间的耦合是许多基于任务的功能神经影像学技术的基础。我们研究了 HIV 感染和以前的 METH 依赖对豆状核 (LN) 内 CBF 的相互作用。24 名 HIV-/METH-、8 名 HIV-/METH+、24 名 HIV+/METH-和 15 名 HIV+/METH+参与者进行了手指敲击范式。协方差的多元回归分析评估了 CBF 与 HIV 血清状态和/或以前 METH 依赖史之间的关联和双向相互作用。HIV+个体的基线 CBF 呈下降趋势（-10%，p=0.07），功能任务的 CBF 变化更大（+32%，p=0.01），而 HIV-个体则呈下降趋势。有以前 METH 依赖史的个体的基线 CBF 较低（-16%，p=0.007），功能任务的 CBF 变化更大（+33%，p=0.02）。然而，基线 CBF（p=0.53）或功能任务的 CBF 变化（p=0.10）之间不存在 HIV 血清状态和以前 METH 依赖史之间的相互作用。此外，LN 中的 CBF 和体积之间没有相关性。HIV 感染和以前 METH 依赖史对 CBF 的可能存在累加关系，以前 METH 依赖史的贡献更大。CBF 的异常可能作为评估 HIV 和以前 METH 依赖对大脑功能的慢性影响的替代测量指标。
