Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
Center of Excellence on Stress and Mental Health, San Diego, CA, USA.
AIDS Behav. 2023 Aug;27(8):2617-2628. doi: 10.1007/s10461-023-03987-4. Epub 2023 Feb 4.
Deficits in social cognition are seen in both people living with HIV (PWH) and people with a history of methamphetamine (METH) dependence. Dually affected individuals may experience additive negative effects on social cognition due to these conditions. We evaluated social cognition in 4 diagnostic groups (HIV-/METH-, HIV-/METH+, HIV+/METH-, HIV+/METH+). First, we used traditional social-emotional functioning assessments, the Difficulties in Emotion Regulation Scale and the Faux Pas Task, to determine any significant effects of METH dependence and HIV on social cognition. Next, we quantified social cognition using the Human Behavioral Pattern Monitor by evaluating social behavior represented by interaction with novel objects. METH dependence significantly affected social-emotional functions and HIV significantly affected on object interactions, however no significant additive effects were observed using these methods. The nuanced relationship between HIV and METH dependence suggests that other factors (i.e., adaptive life skills) likely mediate social cognition-related behaviors.
社会认知缺陷既可见于 HIV 感染者（PWH），也可见于有过甲基苯丙胺（METH）依赖史的人群。双重影响的个体可能会因这些情况而对社会认知产生叠加的负面影响。我们评估了 4 个诊断组（HIV-/METH-、HIV-/METH+、HIV+/METH-、HIV+/METH+）的社会认知。首先，我们使用传统的社会情感功能评估工具，即情绪调节困难量表和失态任务，来确定 METH 依赖和 HIV 对社会认知的显著影响。接下来，我们使用人类行为模式监测器通过评估与新物体的交互来量化社会认知。METH 依赖显著影响社会情感功能，HIV 显著影响物体交互，但使用这些方法未观察到显著的叠加效应。HIV 和 METH 依赖之间的微妙关系表明，其他因素（例如，适应生活的技能）可能会调节与社会认知相关的行为。
