Department of Surgery, Fukuoka Higashi Medical Center, 1-1-1 Chidori, Koga, 811-3195, Japan.
Surg Today. 2011 Apr;41(4):510-3. doi: 10.1007/s00595-009-4297-x. Epub 2011 Mar 23.
Preoperative elevation of serum C-reactive protein (CRP) is a prognostic indicator for some malignant tumors. We investigated the clinicopathologic importance of an elevated preoperative serum CRP value in gastric carcinoma patients.
We studied the relationship between the preoperative serum CRP value and clinicopathologic characteristics in 204 patients who underwent curative resection of gastric carcinoma.
The patients with preoperative CRP elevation had significantly poorer survival than those without CRP elevation (P < 0.0001). According to multivariate analysis, the factors independently associated with an unfavorable prognosis were a high preoperative CRP value (P = 0.024), lymphatic invasion (P = 0.017) and advanced tumor stage (P = 0.016).
Preoperative serum CRP elevation can be an independent prognostic indicator in patients with gastric carcinoma.
术前血清 C 反应蛋白（CRP）升高是某些恶性肿瘤的预后指标。我们研究了术前血清 CRP 值升高对胃癌患者的临床病理重要性。
我们研究了 204 例接受胃癌根治性切除术患者的术前血清 CRP 值与临床病理特征之间的关系。
术前 CRP 升高的患者与 CRP 不升高的患者相比，生存明显较差（P<0.0001）。多因素分析显示，与预后不良相关的独立因素是术前 CRP 值高（P=0.024）、淋巴管浸润（P=0.017）和肿瘤分期较晚（P=0.016）。
术前血清 CRP 升高可作为胃癌患者的独立预后指标。
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