Feng Ji-Feng, Chen Sheng, Yang Xun
Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China.
Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Hangzhou 310022, China.
Oncotarget. 2017 Jun 27;8(38):63132-63139. doi: 10.18632/oncotarget.18667. eCollection 2017 Sep 8.
We initially proposed a useful and novel prognostic model, named CCS [Combination of c-reactive protein (CRP) and squamous cell carcinoma antigen (SCC)], for predicting the postoperative survival in patients with esophageal squamous cell carcinoma (ESCC).
Two hundred and fifty-two patients with resectable ESCC were included in this retrospective study. A logistic regression was performed and yielded a logistic equation. The CCS was calculated by the combined CRP and SCC. The optimal cut-off value for CCS was evaluated by X-tile program. Univariate and multivariate analyses were used to evaluate the predictive factors. In addition, a novel nomogram model was also performed to predict the prognosis for patients with ESCC.
In the current study, CCS was calculated as CRP+6.33 SCC according to the logistic equation. The optimal cut-off value was 15.8 for CCS according to the X-tile program. Kaplan-Meier analyses demonstrated that high CCS group had a significantly poor 5-year cancer-specific survival (CSS) than low CCS group (10.3% vs. 47.3%, <0.001). According to multivariate analyses, CCS ( =0.004), but not CRP ( =0.466) or SCC ( =0.926), was an independent prognostic factor. A nomogram could be more accuracy for CSS (Harrell's c-index: 0.70).
The CCS is a usefull and independent predictive factor in patients with ESCC.
我们最初提出了一种有用且新颖的预后模型，名为CCS[C反应蛋白（CRP）与鳞状细胞癌抗原（SCC）的组合]，用于预测食管鳞状细胞癌（ESCC）患者的术后生存率。
本回顾性研究纳入了252例可切除的ESCC患者。进行逻辑回归分析并得出一个逻辑方程。通过联合CRP和SCC计算CCS。使用X-tile程序评估CCS的最佳临界值。采用单因素和多因素分析来评估预测因素。此外，还构建了一种新颖的列线图模型来预测ESCC患者的预后。
在本研究中，根据逻辑方程，CCS计算为CRP + 6.33 SCC。根据X-tile程序，CCS的最佳临界值为15.8。Kaplan-Meier分析表明，高CCS组的5年癌症特异性生存率（CSS）显著低于低CCS组（10.3%对47.3%，<0.001）。多因素分析显示，CCS（=0.004）是独立的预后因素，而CRP（=0.466）或SCC（=0.926）不是。列线图对CSS的预测可能更准确（Harrell's c指数：0.70）。
CCS是ESCC患者有用的独立预测因素。
