Laubie M, Schmitt H
Eur J Pharmacol. 1978 Nov 1;52(1):99-107. doi: 10.1016/0014-2999(78)90026-2.
The effects of piribedil on responses to sympathetic stimulation were investigated in anaesthetized dogs. Piribedil (1 mg/kg i.v.) impaired the vasoconstrictor responses to lumbar sympathetic chain stimulation of the perfused hindlimb without changing the effects of noradrenaline. Piribedil (2 mg/kg i.v.) depressed the chronotropic responses to stimulation of the right anterior ansa and the inotropic response to stimulation of the left anterior ansa. Stimulation of the splanchnic nerve induced frequency dependent increases in systemic blood pressure. Piribedil antagonized this effect. Piribedil (1 mg/kg i.v.) attenuated the constrictor responses of the perfused mesenteric artery to postganglionic sympathetic stimulation and reduced the decreases in renal blood flow caused by stimulation of sympathetic renal nerves. The inhibitory efforts of piribedil were preferential on responses induced by low frequency stimulation of nerves. The hypertensive, vasoconstrictor and tachycardic effects of noradrenaline and tyramine were not affected. The effects of piribedil were reversed by haloperidol (0.5 mg/kg i.v.) or pimozide (0.2 mg/kg i.v.).
在麻醉犬中研究了吡贝地尔对交感神经刺激反应的影响。静脉注射吡贝地尔（1毫克/千克）损害了灌注后肢对腰交感神经链刺激的血管收缩反应，而不改变去甲肾上腺素的作用。静脉注射吡贝地尔（2毫克/千克）抑制了对右前袢刺激的变时反应和对左前袢刺激的变力反应。刺激内脏神经可引起全身血压频率依赖性升高。吡贝地尔拮抗了这种作用。静脉注射吡贝地尔（1毫克/千克）减弱了灌注肠系膜动脉对节后交感神经刺激的收缩反应，并减少了交感肾神经刺激引起的肾血流量下降。吡贝地尔的抑制作用优先作用于神经低频刺激诱导的反应。去甲肾上腺素和酪胺的升压、血管收缩和心动过速作用不受影响。氟哌啶醇（静脉注射0.5毫克/千克）或匹莫齐特（静脉注射0.2毫克/千克）可逆转吡贝地尔的作用。
