两种锑化合物（三氧化二锑和酒石酸锑钾）在大鼠和小鼠中的睾丸毒性评价。
Testicular toxicity evaluation of two antimony compounds, antimony trioxide and antimony potassium tartrate, in rats and mice.
机构信息
Department of Hygiene, Graduate School of Medical Sciences, Kyushu University, 812-8582, Fukuoka, Japan.
出版信息
Environ Health Prev Med. 2002 Apr;7(1):15-8. doi: 10.1007/BF02898061.
OBJECTIVES
Testicular toxicities of antimony compounds were evaluated in rats and mice. The slightly water-soluble antimony compound antimony trioxide (ATO) and the highly water-soluble antimony compound antimony potassium tartrate (APT) were examined.
METHODS
Daily doses of the compounds were 27.4, 12.0 and 1,200 mg/kg body weight in the APT group, low-ATO group and high-ATO group, respectively. The corresponding daily doses of antimony were 10, 10 and 1,000 mg/kg body weight, in the APT group, low-ATO group and high-ATO group, respectively. Both compounds were administered by gavage: rats, 3 days per week for 4 weeks; mice, 5 days per week for 4 weeks.
RESULTS
Neither compound reduced the weights of reproductive organs or accessory sex organs nor affected sperm parameters. Few marked histopathologic changes were found in the testes of the treated animals. Even at 1,200 mg/kg body weight, which is greater than the LD(50) of APT, ATO produced no effects.
CONCLUSIONS
In this study, it was found that ATO and APT are not toxic to testes in rodents.
目的
评估了几种锑化合物对大鼠和小鼠的睾丸毒性。检测了略溶于水的三氧化二锑（ATO）和高水溶性的酒石酸锑钾（APT）这两种锑化合物。
方法
APT 组、低 ATO 组和高 ATO 组每日分别给予化合物剂量 27.4、12.0 和 1200mg/kg 体重；APT 组、低 ATO 组和高 ATO 组每日给予的锑剂量分别为 10、10 和 1000mg/kg 体重。两种化合物均通过灌胃给药：大鼠每周 3 天，共 4 周；小鼠每周 5 天，共 4 周。
结果
两种化合物均未降低生殖器官和附属生殖器官的重量，也未影响精子参数。处理动物的睾丸中仅发现少数明显的组织病理学变化。即使给予大于 APT 的 LD50（半数致死量）的 1200mg/kg 体重，ATO 也没有产生任何影响。
结论
在这项研究中发现，ATO 和 APT 对啮齿动物的睾丸没有毒性。
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