百草枯的细胞毒性机制。
Mechanism of cytotoxicity of paraquat.
机构信息
Department of Public Health, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan,
出版信息
Environ Health Prev Med. 2002 Jul;7(3):89-94. doi: 10.1265/ehpm.2002.89.
Abstract
Acute paraquat poisoning seems to be very complex because many possible mechanisms of paraquat cytotoxicity have been reported. Some may not be the cause of paraquat poisoning but the result or an accompanying phenomenon of paraquat action. The mechanism critical for cell damage is still unknown. Paraquat poisoning is probably a combination of several paraquat actions. Arguing which mechanism is more critical may not be important, and these clarified mechanisms should be connected and utilized in the development of treatment for paraquat poisoning. Many people still die of pulmonary fibrosis after paraquat exposure. The next target of study will be to verify the mechanism of pulmonary fibrosis by paraquat on the basis of the outcome of studies such as this review.
摘要
急性百草枯中毒似乎非常复杂，因为已经报道了许多百草枯细胞毒性的可能机制。有些可能不是百草枯中毒的原因，而是百草枯作用的结果或伴随现象。对细胞损伤起关键作用的机制尚不清楚。百草枯中毒可能是几种百草枯作用的结合。争论哪种机制更关键可能并不重要，这些阐明的机制应该相互关联，并应用于百草枯中毒的治疗开发中。许多人在接触百草枯后仍死于肺纤维化。下一个研究目标将是在本综述等研究结果的基础上，通过百草枯来验证肺纤维化的机制。
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