Division of Community and Environmental Health, Department of Environmental Health, Tokai University School of Medicine, 259-11, Bohseidai, Isehara, Kanagawa, Japan.
Environ Health Prev Med. 1996 Jul;1(2):87-92. doi: 10.1007/BF02931196.
Pregnant rats were given 0%-, 5%-, 10%- and 20% ethyl alcohol in drinking water during the gestation period.We evaluated the brain function of pups born of alcohol-administered dams. Learning ability (Sidman avoidance behavior), the amounts of monoamines (noradrenalin, dopamine, serotonin) and metabolites (3,4-dihydroxyphenyl acetic acid [DOPAC], homovanillic acid [HVA] and 5-hydroxyindole acetic acid [5-HIAA])in whole brain were examined for neurobehavioral and neurochemical effects.There was no effect on Sidman avoidance behavior in 56-day-old offspring, but alterations of the amounts of monoamines and their metabolites were observed even in 66-day-old offspring as a result of the dams' exposure to ethanol during pregnancy.
孕期给怀孕老鼠喂饮 0%、5%、10%和 20%的乙醇水。我们评估了酒精处理的母鼠所生幼鼠的大脑功能。学习能力（西曼回避行为）、单胺类物质（去甲肾上腺素、多巴胺、血清素）及其代谢物（全脑 3,4-二羟苯乙酸[DOPAC]、高香草酸[HVA]和 5-羟吲哚乙酸[5-HIAA]）的含量都用于神经行为和神经化学的影响。在 56 天大的后代中，西曼回避行为没有受到影响，但由于母鼠在怀孕期间摄入乙醇，66 天大的后代的单胺类物质及其代谢物的含量发生了变化。
