Kalsbeek A, Feenstra M G, van Galen H, Uylings H B
Netherlands Institute for Brain Research, Amsterdam.
Brain Res. 1989 Feb 13;479(2):339-43. doi: 10.1016/0006-8993(89)91637-5.
Monoamine metabolism was determined in the medial prefrontal cortex (mPFC) and the limbic forebrain (LFB) of adult rats following neonatal lesions of the ventral tegmental area. The dopamine (DA) and serotonin (5-HT) levels were decreased down to 30% in both the mPFC and the LFB. The noradrenaline (NA) level was also significantly decreased, but only in the mPFC of the right hemisphere. The metabolite/transmitter ratios of DA and 5-HT, but not of NA, were greatly increased in the depleted mPFC, but not in the LFB, which suggests an increased activity of the remaining cortical DA and 5-HT fibres in the mPFC.
在腹侧被盖区新生期损伤后的成年大鼠内侧前额叶皮质（mPFC）和边缘前脑（LFB）中测定单胺代谢。mPFC和LFB中的多巴胺（DA）和5-羟色胺（5-HT）水平均降至30%。去甲肾上腺素（NA）水平也显著降低，但仅在右半球的mPFC中。在耗尽的mPFC中，DA和5-HT的代谢物/递质比率大幅增加，而在LFB中未增加，这表明mPFC中剩余皮质DA和5-HT纤维的活性增加。
