尿 17-KS 和 17-OHCS 作为空气污染对小学生内分泌干扰的标志物。

Urinary 17-KS and 17-OHCS as markers of endocrine disruption by air pollution in primary school children.

机构信息

Department of Environmental Health, Tokyo Metropolitan Research Laboratory of Public Health, 24-1 Hyakunincho 3 chome, 169, Shinjuku-ku, Tokyo, Japan.

出版信息

Environ Health Prev Med. 2000 Jan;4(4):221-3. doi: 10.1007/BF02931262.

DOI:10.1007/BF02931262

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2723600/

Abstract

The present study was undertaken to determine the effects of air pollution on urinary excretion of 17-ketosteroids (17-KS) and 17-hydroxycorticosteroids (17-OHCS), which are markers of adrenal cortex functions, in primary school children from five schools with different levels of air pollution. One hundred and twentynine fourth-grade children were included in the study. Urinary excretion of 17-KS and 17-OHCS were significantly lower in male children living in polluted areas than in children living in clean areas. We conclude that adrenal cortex functions before puberty can serve as practical markers of endocrine disruption by environmental factors in epidemiological studies.

摘要

本研究旨在确定空气污染对来自五个空气污染程度不同的学校的小学生尿液中 17-酮类固醇（17-KS）和 17-羟皮质类固醇（17-OHCS）排泄的影响，这两种物质是肾上腺皮质功能的标志物。研究纳入了 129 名四年级儿童。生活在污染地区的男童尿液中 17-KS 和 17-OHCS 的排泄量明显低于生活在清洁地区的儿童。我们得出结论，青春期前的肾上腺皮质功能可以作为环境因素对内分泌干扰的实用标志物，用于流行病学研究。

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