神经退行性疾病中的述情障碍
Alexithymia in neurodegenerative disease.
作者信息
Sturm Virginia E, Levenson Robert W
机构信息
Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
出版信息
Neurocase. 2011 Jun;17(3):242-50. doi: 10.1080/13554794.2010.532503.
We investigated alexithymia, a deficit in the ability to identify and describe one's emotions, in a sample that included patients with neurodegenerative disease and healthy controls. In addition, we investigated the relationship that alexithymia has with behavioral disturbance and with regional gray matter volumes. Alexithymia was examined with the Toronto Alexithymia Scale-20, behavioral disturbance was assessed with the Neuropsychiatric Inventory, and regional gray matter volumes were obtained from structural magnetic resonance images. Group analyses revealed higher levels of alexithymia in patients than controls. Alexithymia scores were positively correlated with behavioral disturbance (apathy and informant distress, in particular) and negatively correlated with the gray matter volume of the right pregenual anterior cingulate cortex, a region of the brain that is thought to play an important role in self and emotion processing.
我们在一个包含神经退行性疾病患者和健康对照的样本中，对述情障碍（一种识别和描述自身情绪能力的缺陷）进行了研究。此外，我们还研究了述情障碍与行为障碍以及与局部灰质体积之间的关系。使用多伦多述情障碍量表-20对述情障碍进行检测，用神经精神科问卷评估行为障碍，并从结构磁共振图像中获取局部灰质体积。组间分析显示，患者的述情障碍水平高于对照组。述情障碍得分与行为障碍（尤其是冷漠和照料者苦恼）呈正相关，与右侧膝前扣带回皮质的灰质体积呈负相关，该脑区被认为在自我和情绪处理中起重要作用。
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