Roos K L, Pascuzzi R M, Kuharik M A, Shapiro A D, Manco-Johnson M J
Department of Neurology, Indiana University School of Medicine, Indianapolis.
Obstet Gynecol. 1990 Sep;76(3 Pt 2):492-4.
Development of intracranial dural sinus thrombosis in the postpartum period has been attributed to the hypercoagulable state of pregnancy. With increasing recognition of the role of the vitamin K-dependent proteins, protein C and protein S, in intracranial venous and arterial thrombotic events, our understanding of the cause of thrombotic events has improved. We report a patient who developed a superior sagittal sinus thrombosis in the second week postpartum, associated with a dysfunctional protein C and a decreased free protein S concentration.
产后颅内硬脑膜窦血栓形成被认为与妊娠期的高凝状态有关。随着对维生素K依赖蛋白、蛋白C和蛋白S在颅内静脉和动脉血栓形成事件中作用的认识不断提高，我们对血栓形成事件原因的理解也有所改善。我们报告了一名患者，其在产后第二周发生上矢状窦血栓形成，伴有蛋白C功能障碍和游离蛋白S浓度降低。
