路易斯碱催化的缺电子色酮衍生杂二烯和炔烃的[4+2]环加成反应。
Lewis base catalyzed [4+2] annulation of electron-deficient chromone-derived heterodienes and acetylenes.
机构信息
Max-Planck-Institut für molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Str. 11, 44227 Dortmund, Germany.
出版信息
Chemistry. 2011 Apr 26;17(18):5130-7. doi: 10.1002/chem.201003572. Epub 2011 Mar 22.
PMID:21432922
Abstract
Lewis base catalyzed [4+2] annulation reactions between electron-deficient chromone oxa- and azadienes and acetylene carboxylates provide tricyclic benzopyrones inspired by natural products. An asymmetric synthesis of the tricyclic benzopyrones was developed by using modified cinchona alkaloids as enantiodifferentiating Lewis base catalysts.
摘要
路易斯碱催化的缺电子色酮氧杂和氮杂二烯与乙炔羧酸酯之间的[4+2]环加成反应为受天然产物启发的三环苯并吡喃类化合物提供了灵感。通过使用修饰的金鸡纳生物碱作为对映体区分的路易斯碱催化剂，开发了三环苯并吡喃类化合物的不对称合成方法。
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