It is well established that osteoporosis and diabetes are prevalent diseases with significant associated morbidity and mortality. The relationship between diabetes and bone disease is less well defined but recent data seem to suggest that diabetes and the complications associated with it can be detrimental to bone health. Furthermore, it appears that thiazolidinediones, medications used in the treatment of diabetes, can also cause bone loss and increase the risk of fracture. This article will review the relationship between diabetes and bone health.