Tchekmedyian N S, Hickman M, Siau J, Greco A, Aisner J
Medical Oncology Section, St. Mary Medical Center, Long Beach, California.
Oncology (Williston Park). 1990 May;4(5):185-92; discussion 194.
The quality of life of patients with advanced cancer depends to a large degree on the presence of disease or treatment-related symptoms. Anorexia is frequent in cancer patients, but has received less attention than other symptoms such as pain or nausea. Yet, anorexia is important because it reduces caloric intake and leads to malnutrition. Further, lack of appetite can disrupt basic activities of daily living, such as eating, and may also interfere with family and social interactions. To test the efficacy of drugs that reverse anorexia, we need accurate and reliable parameters to quantitate this symptom. The effects of anorexia and its reversal on the patients' clinical progress, food intake, nutritional status, and quality of life need to be evaluated. Our ongoing studies demonstrate that megestrol acetate can reverse cancer anorexia and that appetite changes strongly correlate with changes in weight, food intake, and quality of life scores.
晚期癌症患者的生活质量在很大程度上取决于疾病或治疗相关症状的存在。厌食症在癌症患者中很常见，但与疼痛或恶心等其他症状相比，受到的关注较少。然而，厌食症很重要，因为它会减少热量摄入并导致营养不良。此外，食欲不振会干扰日常生活的基本活动，如进食，还可能影响家庭和社会交往。为了测试逆转厌食症药物的疗效，我们需要准确可靠的参数来量化这一症状。需要评估厌食症及其逆转对患者临床进程、食物摄入量、营养状况和生活质量的影响。我们正在进行的研究表明，醋酸甲地孕酮可以逆转癌症厌食症，并且食欲变化与体重、食物摄入量和生活质量评分的变化密切相关。
