Ravindra K, Ramachander T
Department of Dermatology, Jaya Jagadguru Murugharajendra Medical College (JJMC), Davangere-577 004, Karanataka, India.
Indian J Lepr. 2010 Apr-Jun;82(2):91-3.
M. leprae is a more prevalent cause of cutaneous infections as compared M. tuberculosis, though both belong to the same family of organisms; their co-existence is a rare entity in children. It has been suggested that cross-immunity exists between tuberculosis and leprosy with reports of BCG vaccine giving some protection against leprosy. In spite of epidemiological, clinical and microbiological evidences; the exact relationship between tuberculosis and leprosy still remains unclear. It is imperative to rule out coexistence of cutaneous tuberculosis and leprosy as therapy with rifampicin in treatment of leprosy can lead to drug resistance in management of tuberculosis and the use of steroid in leprosy can aggravate cutaneous tuberculosis.
尽管结核分枝杆菌和麻风分枝杆菌属于同一生物家族，但与结核分枝杆菌相比，麻风分枝杆菌是皮肤感染更常见的病因；它们在儿童中同时存在的情况很少见。有人提出结核病和麻风病之间存在交叉免疫，有报告称卡介苗对麻风病有一定的预防作用。尽管有流行病学、临床和微生物学证据，但结核病和麻风病的确切关系仍不清楚。必须排除皮肤结核和麻风病的共存，因为在麻风病治疗中使用利福平会导致结核病治疗中出现耐药性，而在麻风病中使用类固醇会加重皮肤结核。
