Department of Pharmaceutical Sciences Dr. Hari Singh Gour Vishwavidyalaya, Sagar, India.
Curr Pharm Des. 2011;17(11):1108-25. doi: 10.2174/138161211795656873.
Bioconjugation, a novel technique is usually exploited to improve the biopharmaceutical aspects of a bioactive as well as afford its spatial and temporal distribution. The strategy enlightens newer vistas for delivery of drugs, peptides, enzymes, and oligonucleotides. Site specific delivery may be obtained by tailoring the conjugates as an inactive prodrug and designing polymer drug linkages susceptible to cleavage by specific enzymes or pH. These prodrugs substantially change the mechanisms of cellular entry, pharmacokinetic disposition and ultimately target the drug. The conjugate vehicles are being exploited for targeting pharmacological agents to visceral tissues viz brain, colon etc. These biomaterials are bringing into play, novel drug delivery systems for selectively and specifically ferrying drugs to the desired organ. Noteworthy contributions reported with bioconjugated nanoparticles for biosensing and bioimaging incorporate cell staining, DNA detection, separation and recombination relevance in DNA protection. Only recently, these tailor-made polymers have also gained impetuous for enzyme therapy, gene therapy, insulin therapy, cancer therapy and management of AIDS with the interception of minimal side effects. The present review exhaustively provides an insight to the polymer bioconjugates and their implications for targeted delivery. The article also discusses the therapeutic aspects of these conjugates and that these may serve as fascinating tools for drug delivery.
生物共轭物是一种新型技术，通常用于改善生物活性物质的生物制药方面，并提供其空间和时间分布。该策略为药物、肽、酶和寡核苷酸的传递提供了新的视角。通过将缀合物设计为无活性前药，并设计对特定酶或 pH 敏感的聚合物药物键，可以实现靶向递药。这些前药会显著改变细胞进入、药代动力学分布的机制，并最终靶向药物。缀合物载体正被用于将药理学制剂靶向内脏组织，如脑、结肠等。这些生物材料正在为选择性和特异性地将药物递送到所需器官发挥作用，新型药物传递系统。值得注意的是，生物共轭纳米粒子在生物传感和生物成像方面的报告包括细胞染色、DNA 检测、分离和重组在 DNA 保护中的相关性。直到最近，这些定制聚合物也因酶治疗、基因治疗、胰岛素治疗、癌症治疗和艾滋病管理而获得了动力，同时可以拦截最小的副作用。本综述全面介绍了聚合物生物共轭物及其在靶向递药中的应用。文章还讨论了这些缀合物的治疗方面，它们可以作为药物传递的迷人工具。
