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Common variant on chromosome 9p21 predicts severity of coronary artery disease.

作者信息

Chan Kenneth, Motterle Anna, Laxton Ross C, Ye Shu

出版信息

J Am Coll Cardiol. 2011 Mar 29;57(13):1497-8; author reply 1498-9. doi: 10.1016/j.jacc.2010.09.078.

DOI:10.1016/j.jacc.2010.09.078
PMID:21435522
Abstract
摘要

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Common variant on chromosome 9p21 predicts severity of coronary artery disease.9号染色体短臂21区的常见变异可预测冠状动脉疾病的严重程度。
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2
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Gene dosage of the common variant 9p21 predicts severity of coronary artery disease.常见变异 9p21 的基因剂量可预测冠状动脉疾病的严重程度。
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A common variant on chromosome 9p21 affects the risk of myocardial infarction.9号染色体短臂21区的一个常见变异影响心肌梗死风险。
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Identifying the susceptibility genes for coronary artery disease: from hyperbole through doubt to cautious optimism.确定冠状动脉疾病的易感基因：从夸张到怀疑再到谨慎乐观。
J Intern Med. 2008 May;263(5):538-52. doi: 10.1111/j.1365-2796.2008.01958.x.
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The 9p21 locus and coronary heart disease: initiator, promoter, or precipitator?9p21基因座与冠心病：起始因素、促进因素还是诱发因素？
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Association of genetic variation on chromosome 9p21.3 and arterial stiffness.9号染色体p21.3区域的基因变异与动脉僵硬度的关联。
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A common variant at chromosome 9P21.3 is associated with age of onset of coronary disease but not subsequent mortality.9号染色体短臂2区1带3亚带的一个常见变异与冠心病发病年龄相关，但与随后的死亡率无关。
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Socioeconomic Status Interacts with the Genetic Effect of a Chromosome 9p21.3 Common Variant to Influence Coronary Artery Calcification and Incident Coronary Events in the Heinz Nixdorf Recall Study (Risk Factors, Evaluation of Coronary Calcium, and Lifestyle).在海因茨·尼克斯多夫召回研究（风险因素、冠状动脉钙化评估和生活方式）中，社会经济地位与9号染色体p21.3常见变异的遗传效应相互作用，影响冠状动脉钙化和冠心病事件。
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Coronary artery calcification and its relationship to validated genetic variants for diabetes mellitus assessed in the Heinz Nixdorf recall cohort.在 Heinz Nixdorf 召回队列中评估冠状动脉钙化及其与经证实的糖尿病遗传变异的关系。
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引用本文的文献

1
Genetics of coronary artery disease - a clinician's perspective.冠心病的遗传学——临床医生视角
Indian Heart J. 2014 Nov-Dec;66(6):663-71. doi: 10.1016/j.ihj.2014.12.008. Epub 2014 Dec 18.
2
Evaluation of association between common genetic variants on chromosome 9p21 and coronary artery disease in Turkish population.土耳其人群中9号染色体短臂21区常见基因变异与冠状动脉疾病之间关联的评估。
Anatol J Cardiol. 2015 Mar;15(3):196-203. doi: 10.5152/akd.2014.5285. Epub 2014 Apr 8.
3
The association of 9p21-3 locus with coronary atherosclerosis: a systematic review and meta-analysis.
9p21-3 位点与冠状动脉粥样硬化的相关性：系统评价和荟萃分析。
BMC Med Genet. 2014 Jun 6;15:66. doi: 10.1186/1471-2350-15-66.
4
Genetic variants at chromosome 9p21 and risk of first versus subsequent coronary heart disease events: a systematic review and meta-analysis.9号染色体p21区域的基因变异与首次及后续冠心病事件风险：一项系统评价和荟萃分析。
J Am Coll Cardiol. 2014 Jun 3;63(21):2234-45. doi: 10.1016/j.jacc.2014.01.065. Epub 2014 Mar 7.
5
Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis.9p21 染色体位点与冠状动脉疾病负担的相关性：一项合作荟萃分析。
J Am Coll Cardiol. 2013 Mar 5;61(9):957-70. doi: 10.1016/j.jacc.2012.10.051. Epub 2013 Jan 23.