Marques Ester Augusta Lima Vinhas, Neves Lidia, Fonseca Tereza Cristina, Lins Mecneide Mendes, Pedrosa Francisco, Lucena-Silva Norma
Pediatric Oncology Service/IMIP Hospital, Brazil.
J Pediatr Hematol Oncol. 2011 Aug;33(6):470-4. doi: 10.1097/MPH.0b013e3181fb8f61.
Translocations involving chromosome 11q23 are frequently found in pediatric leukemia, especially in infants. The mixed lineage leukemia (MLL)-AF4 fusion/t(4;11) is mostly found in acute lymphoblastic leukemia (ALL) and MLL-AF9 fusion/t(9;11) in acute myeloid leukemia (AML). We study 441 consecutive new cases of childhood leukemia diagnosed in Brazil. Chromosomal translocation was determined solely by conventional polymerase chain reaction (PCR) in 72 out of 265 ALL and in 43 out of 103 AML. MLL-AF4 fusion/t(4;11) was detected in 3 out of 265 ALL and MLL-AF9 fusion/t(9;11) in 4 out of 103 of AML. MLL-rearrangements were presented in 7 out of 23 infant leukemia, whose 5 were MLL-ENL fusion/t(11;19). No fusion MLL-AF4 fusion/t(4;11) was found. Other translocation frequencies differed from that reported for an American population suggesting interethnic differences on chromosomal translocations frequencies in acute leukemia.
涉及11号染色体q23的易位在小儿白血病中经常发现，尤其是在婴儿中。混合谱系白血病（MLL）-AF4融合/t(4;11)大多见于急性淋巴细胞白血病（ALL），而MLL-AF9融合/t(9;11)见于急性髓细胞白血病（AML）。我们研究了在巴西诊断的441例连续新发儿童白血病病例。在265例ALL中的72例以及103例AML中的43例中，染色体易位仅通过常规聚合酶链反应（PCR）确定。在265例ALL中有3例检测到MLL-AF4融合/t(4;11)，在103例AML中有4例检测到MLL-AF9融合/t(9;11)。在23例婴儿白血病中有7例出现MLL重排，其中5例为MLL-ENL融合/t(11;19)。未发现MLL-AF4融合/t(4;11)。其他易位频率与报道的美国人群不同，表明急性白血病染色体易位频率存在种族差异。
