Pharmacy Health Care Administration, Department of Pharmacy Practice, University of Toledo, Ohio, USA.
J Asthma Allergy. 2010 Aug 24;3:101-6. doi: 10.2147/JAA.S11683.
Despite the presence of existing guidelines, underuse of inhaled corticosteroids (ICSs) still exists among patients with persistent asthma in the United States. Inappropriate utilization of asthma medications has been attributed as one of the reasons for the significant economic burden due to asthma.
To determine the demographic factors predicting patient-reported use of ICSs among patients with asthma.
The study utilized data from the 4-state sample of the National Asthma Survey (NAS), sponsored by the National Center for Environmental Health (NCEH), Centers for Disease Control and Prevention (CDC). The study population consisted of patients with persistent asthma as defined by National Heart, Lung, and Blood Institute (NHLBI) guidelines. Frequency distributions were made to characterize the study population. Logistic regression analysis was carried out to determine the odds of reported use of ICSs across various demographic variables (age, gender, race, income level, insurance coverage, and disease severity). Data were analyzed using SAS v9.0 software.
Underutilization of ICSs was found to exist in the patients with asthma, as more than half of the study population (52.8%, n = 304) did not report the use of ICSs. African American patients were found to have much lower odds for use of ICSs (odds ratio [OR] = 0.495; confidence interval [CI], 0.248-0.987) when compared with whites. Insured patients had significantly higher odds for the use of ICSs (OR = 2.378; CI, 1.106-5.110) compared with uninsured patients. The findings held true even after adjusting for other demographic factors.
Underuse of ICSs continues to be a problem in patients with asthma. Vulnerable populations identified in this study are targeted for the use of ICSs. The importance of adherence to treatment and use of ICSs is an issue that needs to be addressed.
尽管存在现有指南,但在美国,持续性哮喘患者仍存在吸入皮质类固醇(ICS)使用不足的情况。哮喘药物的使用不当被认为是哮喘造成巨大经济负担的原因之一。
确定预测哮喘患者报告使用 ICS 的人口统计学因素。
该研究利用了由国家环境健康中心(NCEH)、疾病控制与预防中心(CDC)赞助的国家哮喘调查(NAS)4 个州样本的数据。研究人群由国家心肺血液研究所(NHLBI)指南定义的持续性哮喘患者组成。进行了频率分布以描述研究人群。进行逻辑回归分析,以确定报告使用 ICS 的各种人口统计学变量(年龄、性别、种族、收入水平、保险覆盖范围和疾病严重程度)的可能性。使用 SAS v9.0 软件进行数据分析。
发现哮喘患者中存在 ICS 使用不足的情况,超过一半的研究人群(52.8%,n=304)未报告使用 ICS。与白人相比,非裔美国患者使用 ICS 的可能性要低得多(比值比[OR] = 0.495;置信区间[CI],0.248-0.987)。与未参保患者相比,参保患者使用 ICS 的可能性显著更高(OR=2.378;CI,1.106-5.110)。即使在调整了其他人口统计学因素后,这些发现仍然成立。
ICS 使用不足仍然是哮喘患者的一个问题。本研究确定的弱势群体是使用 ICS 的目标人群。需要解决的问题是坚持治疗和使用 ICS 的重要性。