Massachusetts General Hospital, Department of Imaging, Division of Cardiovascular Imaging and Intervention, 55 Fruit Street, GRB-290, Boston, MA 02114-2696, USA.
Eur J Radiol. 2012 Jun;81(6):1371-5. doi: 10.1016/j.ejrad.2011.03.017. Epub 2011 Mar 25.
To compare clinical and imaging outcomes after uterine fibroid embolization (UFE) with Embosphere versus Bead Block microspheres.
Our institutional review board approved this HIPAA-compliant study. We conducted a retrospective review of all consecutive UFEs performed for symptomatic uterine fibroids at our academic institution from 2001 to 2008. UFE was performed using Embosphere (n = 70) or Bead Block (n = 55) microspheres. Patient symptoms and MR images were reviewed before and following UFE. The MR images were analyzed for changes in the size and contrast enhancement of the dominant fibroid and the uterus.
125 patients underwent UFE. Pre-treatment characteristics (patient age, presenting symptoms, fibroid location, and volume of the largest fibroid) were similar across groups. Procedure endpoint (near-stasis, reached in 94% of cases), duration, and sedation medication doses were also similar. Clinical follow-up was available in 69 (55%) patients (mean duration: 13.6 months). Of these, 92% had clinical improvement of their main presenting symptom(s) and 3% developed early menopause. MRI follow-up was available in 105 (84%) patients (mean 7.8 months). Mean volume reduction of the largest fibroid was similar after Embosphere (48%) and Bead Block (53%, p = NS). Residual enhancement ≥ 5% in the dominant fibroid was similarly uncommon after Bead Block (19%) or Embosphere (16%, p = NS). Mean uterine volume reduction was similar across groups (38%); no myometrial infarction occurred.
This retrospective study showed no superiority of Embosphere over Bead Block microspheres in terms of clinical and imaging outcomes after UFE.
比较子宫纤维瘤栓塞术（UFE）中使用 Embosphere 与 Bead Block 微球的临床和影像学结果。
本机构审查委员会批准了这项符合 HIPAA 规定的研究。我们对 2001 年至 2008 年在我们学术机构进行的所有因症状性子宫纤维瘤而接受 UFE 的连续患者进行了回顾性研究。UFE 使用 Embosphere（n=70）或 Bead Block（n=55）微球进行。在 UFE 前后对患者症状和磁共振成像（MRI）图像进行了回顾。对主导性纤维瘤和子宫的大小和对比增强变化进行了 MRI 分析。
125 名患者接受了 UFE。各组患者的治疗前特征（患者年龄、症状、纤维瘤位置和最大纤维瘤体积）相似。治疗终点（接近静止状态，94%的病例达到）、持续时间和镇静药物剂量也相似。69 名（55%）患者可获得临床随访（平均随访时间：13.6 个月）。其中 92%的患者主要症状得到改善，3%的患者出现早期绝经。105 名（84%）患者可获得 MRI 随访（平均随访时间：7.8 个月）。Embosphere（48%）和 Bead Block（53%，p=NS）后最大纤维瘤的平均体积减少相似。Bead Block（19%）或 Embosphere（16%，p=NS）后主导性纤维瘤残留增强≥5%同样罕见。各组子宫体积减少相似（38%）；无子宫肌层梗死发生。
这项回顾性研究表明，在 UFE 后的临床和影像学结果方面，Embosphere 并不优于 Bead Block 微球。
