FOXO、TOR和Akt之间的相互作用。
Interplay between FOXO, TOR, and Akt.
作者信息
Hay Nissim
机构信息
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, IL 60607, USA.
出版信息
Biochim Biophys Acta. 2011 Nov;1813(11):1965-70. doi: 10.1016/j.bbamcr.2011.03.013. Epub 2011 Apr 1.
Abstract
FOXO transcription factors have emerged as rheostats that coordinate the activities of Akt and targets of rapamycin complexes (TORCs). This review summarizes the regulatory circuits mediated by the activation of FOXO, which in turn modulate Akt and TORCs activities. The biological significance of these regulatory circuits is discussed in this article. This article is part of a Special Issue entitled: P13K-AKT-FoxO axis in cancer and aging.
摘要
叉头框O（FOXO）转录因子已成为协调Akt和雷帕霉素靶蛋白复合物（TORCs）活性的变阻器。本综述总结了由FOXO激活介导的调控通路，这些通路反过来调节Akt和TORCs的活性。本文讨论了这些调控通路的生物学意义。本文是名为“癌症与衰老中的P13K-AKT-FoxO轴”特刊的一部分。
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AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity.
Cancer Cell. 2011 Jan 18;19(1):58-71. doi: 10.1016/j.ccr.2010.10.031. Epub 2011 Jan 6.
2
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.
Science. 2011 Jan 28;331(6016):456-61. doi: 10.1126/science.1196371. Epub 2010 Dec 23.
3
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging.
Cell. 2010 Nov 24;143(5):813-25. doi: 10.1016/j.cell.2010.10.007.
4
Understanding Forkhead box class O function: lessons from Drosophila melanogaster.
Antioxid Redox Signal. 2011 Feb 15;14(4):635-47. doi: 10.1089/ars.2010.3407. Epub 2010 Oct 20.
5
With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging.
Cell Metab. 2010 Jun 9;11(6):453-65. doi: 10.1016/j.cmet.2010.05.001.
6
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J Biol Chem. 2010 May 21;285(21):15960-5. doi: 10.1074/jbc.M110.121871. Epub 2010 Apr 6.
8
The genetics of ageing.
Nature. 2010 Mar 25;464(7288):504-12. doi: 10.1038/nature08980.
9
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies.
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10
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