Department of Physics, University of Trento, Trento, Italy.
J Colloid Interface Sci. 2011 Jun 1;358(1):86-92. doi: 10.1016/j.jcis.2011.03.006. Epub 2011 Mar 8.
Silicon nanocrystals were made hydrophilic by 10-undecenoic acid grafting and were then coated with sodium deoxycholate, a detergent-like compound belonging to the bile acid class which is crucial for absorption of lipids in the small intestine. The resulting silicon nanocrystals have an average diameter of 3-5 nm, can be dispersed in aqueous solutions and show stable photoluminescence. Coating with non-biological surfactants, which are dangerous for cell safety, was investigated for comparison. Results indicate that deoxycholate is a stabilizer of luminescent silicon nanocrystals. Deoxycholate coated nanocrystals appear suitable for applications as multifunctional probes in biomedicine.
硅纳米晶通过十一烯酸接枝使其亲水，然后用去氧胆酸钠进行包覆。去氧胆酸钠是一种属于胆汁酸类的去污剂化合物，对小肠吸收脂质至关重要。所得硅纳米晶的平均直径为 3-5nm，可分散在水溶液中，并显示出稳定的光致发光。为了进行比较，还研究了用对细胞安全性有危险的非生物表面活性剂进行包覆。结果表明，去氧胆酸钠是发光硅纳米晶的稳定剂。去氧胆酸钠包覆的纳米晶似乎适合用作生物医学中的多功能探针。
