Sufit R L, Kreul J F, Bellay Y M, Helmer P, Brunson D B, Will J
Department of Neurology, School of Medicine, University of Wisconsin-Madison 53792.
Anesth Analg. 1990 Sep;71(3):285-7. doi: 10.1213/00000539-199009000-00012.
The role of succinylcholine in the precipitation of malignant hyperthermia (MH) necessitates the testing of new neuromuscular relaxants for their ability to trigger MH in MH-susceptible swine before general human use. We tested doxacurium and mivacurium, two new nondepolarizing bis-benzylisoquinolinium neuromuscular relaxants, at ED95 and at four times ED95 doses in swine previously documented to be MH-susceptible. In none of the 16 animals was MH triggered after administration of these relaxants, whereas all animals developed fatal MH after administration of halothane or halothane plus succinylcholine. Muscle biopsy specimens taken before administration of the relaxant confirmed that all animals had increased sensitivity to halothane, caffeine, or both. Thus, we conclude that doxacurium and mivacurium are not triggering agents of malignant hyperthermia in MH-susceptible swine.
琥珀酰胆碱在恶性高热（MH）诱发过程中的作用，使得在新的神经肌肉阻滞剂用于人类之前，有必要检测其在易患MH的猪中触发MH的能力。我们在先前记录为易患MH的猪中，以ED95和四倍ED95剂量测试了两种新型非去极化双苄基异喹啉类神经肌肉阻滞剂多沙库铵和米库氯铵。在给予这些松弛剂后，16只动物中没有一只触发MH，而所有动物在给予氟烷或氟烷加琥珀酰胆碱后都发生了致命的MH。在给予松弛剂之前采集的肌肉活检标本证实，所有动物对氟烷、咖啡因或两者的敏感性均增加。因此，我们得出结论，多沙库铵和米库氯铵不是易患MH的猪中恶性高热的触发剂。
