恶性高热易感猪的丙泊酚麻醉
Propofol anaesthesia in malignant hyperpyrexia susceptible swine.
作者信息
Foster P S, Hopkinson K C, Denborough M A
机构信息
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT.
出版信息
Clin Exp Pharmacol Physiol. 1992 Mar;19(3):183-6. doi: 10.1111/j.1440-1681.1992.tb00436.x.
Abstract
- Malignant hyperpyrexia (MH) is an inherited muscle abnormality that presents clinically as a syndrome of life-threatening complications during general anaesthesia. 2. Propofol is a new sedative hypnotic used for the induction and maintenance of anaesthesia. 3. Propofol did not induce MH in five susceptible pigs. Propofol did not induce contracture in isolated MH susceptible muscle but did modify halothane, caffeine and KCl contractures.
摘要
- 恶性高热（MH）是一种遗传性肌肉异常，在全身麻醉期间临床上表现为危及生命的并发症综合征。2. 丙泊酚是一种用于麻醉诱导和维持的新型镇静催眠药。3. 丙泊酚在五只易感猪中未诱发MH。丙泊酚在离体的MH易感肌肉中未诱发挛缩，但确实改变了氟烷、咖啡因和氯化钾诱发的挛缩。
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