Parija Satyajeet, Kumar Amit
BioAxis DNA Research Centre Pvt. Ltd., Gomtinagar Lucknow, India.
Int J Bioinform Res Appl. 2011;7(1):1-14. doi: 10.1504/IJBRA.2011.039166.
A vast majority of the ovarian and the breast cancers are sporadic and result from the accumulation of genetic damage. Most preclinical data suggest that women experiencing ovarian cancer are prone to breast cancer and vice versa. Similar domains and similar binding sites often imply similar protein?protein interactions and similar functions. Zinc finger of P53 and Ring finger of BRCA1 are similar domains having mostly binding activity. BRCT domain of BRCA1 is helpful in DNA-damage repair and cell cycle checkpoint functioning. This study sets out to check similar pattern, domain and residue-specific mutation, which may interact with expressions of P53 and BRCA1.
绝大多数卵巢癌和乳腺癌是散发性的，由基因损伤的积累所致。大多数临床前数据表明，患卵巢癌的女性易患乳腺癌，反之亦然。相似的结构域和相似的结合位点通常意味着相似的蛋白质-蛋白质相互作用和相似的功能。P53的锌指结构和BRCA1的环指结构是具有主要结合活性的相似结构域。BRCA1的BRCT结构域有助于DNA损伤修复和细胞周期检查点功能。本研究旨在检查可能与P53和BRCA1表达相互作用的相似模式、结构域和残基特异性突变。
