Department of Human Developmental Biology, Jagiellonian University, College of Medicine, Kopernika 7, PL 31-034 Kraków, Poland.
Pharmacol Rep. 2011;63(1):30-44. doi: 10.1016/s1734-1140(11)70396-6.
IL-17 is a multifunctional cytokine produced by activated CD4+ and CD8+ lymphocytes as well as stimulated unconventional Tγδ and natural killer T cells. IL-17 induces expression of chemokines, proinflammatory cytokines and metalloproteinases, thereby stimulating the inflammation and chemotaxis of neutrophils. Elevation of proinflammatory cytokines is associated with asthma and autoimmune disorders, such as multiple sclerosis, rheumatoid arthritis and psoriasis. Although the role of IL-17 in these disorders is not always easy to define, extensive research has demonstrated an aggravating influence of IL-17 in some animal models. Thus, the development of therapeutics to reduce IL-17 levels is a promising strategy for ameliorating inflammatory diseases. This review briefly summarizes recent knowledge about stimulants and intracellular signaling pathways that induce development and maturation of IL-17-expressing cells. Its positive and negative roles on disease progression and its importance in vaccine-induced memory are also discussed. Finally, recent literature describing potential therapeutic approaches for targeting IL-17 is presented.
白细胞介素-17 是一种多功能细胞因子，由活化的 CD4+和 CD8+淋巴细胞以及受刺激的非常规 Tγδ 和自然杀伤 T 细胞产生。白细胞介素-17 诱导趋化因子、促炎细胞因子和金属蛋白酶的表达，从而刺激中性粒细胞的炎症和趋化作用。促炎细胞因子的升高与哮喘和自身免疫性疾病有关，如多发性硬化症、类风湿关节炎和银屑病。尽管白细胞介素-17 在这些疾病中的作用并不总是容易确定，但广泛的研究表明，白细胞介素-17 在一些动物模型中具有加重作用。因此，开发降低白细胞介素-17 水平的疗法是改善炎症性疾病的一种有前途的策略。本综述简要总结了诱导产生白细胞介素-17 表达细胞的发育和成熟的刺激物和细胞内信号通路的最新知识。还讨论了它在疾病进展中的正反两方面作用及其在疫苗诱导记忆中的重要性。最后，介绍了描述针对白细胞介素-17 的潜在治疗方法的最新文献。
