Devereux D F
Melanoma Pigmented Lesion Center, UMDNJ-Robert Wood Johnson Medical School.
Oncology (Williston Park). 1990 Jan;4(1):73-81; discussion 82-3.
Malignant melanoma may arise de novo as well as in association with pre-existing dysplastic nevi. The latter serve as markers, since people who have them are at a higher risk for the development of malignant melanoma than is the general population. Patients with the syndrome should be examined carefully, including the scalp and eyes, every three to six months. Suspicious nevi should be photographed and biopsied, and a family history taken. Excision of dysplastic nevi may be indicated in patients with a positive family history for malignant melanoma, due to the high risk of developing a cutaneous melanoma. We need to educate patients regarding the need for continued follow-up, self-examination, and avoidance of sun exposure.
恶性黑色素瘤可原发产生，也可与先前存在的发育异常痣相关联出现。后者可作为标志物，因为患有发育异常痣的人患恶性黑色素瘤的风险高于普通人群。患有该综合征的患者应每三到六个月接受仔细检查，包括头皮和眼睛。可疑痣应拍照并进行活检，并记录家族史。对于有恶性黑色素瘤家族史阳性的患者，由于发生皮肤黑色素瘤的风险较高，可能需要切除发育异常痣。我们需要教育患者持续随访、自我检查以及避免阳光照射的必要性。
