Department of Internal Medicine, Taichung Tzu Chi General Hospital, Taichung County, Taiwan.
Am J Med Sci. 2011 Apr;341(4):301-4. doi: 10.1097/MAJ.0b013e3181ff5d93.
The purpose of this study was to explore the potential risk factors of hepatocellular carcinoma (HCC) recurrence after curative resection of primary HCC.
This was a hospital-based retrospective cohort study. The authors analyzed the medical records of all the subjects with HCC initially treated by hepatic resection at a medical center in Taiwan from 1995 to 2006. In all, 222 subjects were enrolled in this study. The total observational period was 3 years.
There were 172 men (77.5%) and 50 women (22.5%). The mean age was 57.0 ± 13.7 years (range, 15-79 years). Among 222 subjects, the overall recurrence rates were 28.8% (64/222), 42.3% (94/222) and 47.7% (106/222) at 1, 2 and 3 years, respectively. Multivariate logistic regression analysis exhibited that tumor size ≥ 5 cm [odds ratio (OR) = 2.31, 95% confidence interval (CI) = 1.27-4.17], liver cirrhosis (OR = 2.11, 95% CI = 1.18-3.79) and preoperative aspartate aminotransferase level ≥ 34 IU/L (OR = 2.02, 95% CI = 1.01-4.04) were independent risk factors of HCC recurrence.
Patients who have larger tumor size, liver cirrhosis and higher preoperative aspartate aminotransferase level should be carefully followed up because they are at high risk of HCC recurrence postoperatively.
本研究旨在探讨原发性肝细胞癌（HCC）根治性切除术后 HCC 复发的潜在危险因素。
这是一项基于医院的回顾性队列研究。作者分析了台湾一家医疗中心 1995 年至 2006 年间接受肝切除术治疗的所有 HCC 患者的病历。本研究共纳入 222 例患者。总观察期为 3 年。
男性 172 例（77.5%），女性 50 例（22.5%）。平均年龄为 57.0±13.7 岁（15-79 岁）。222 例患者中，总的复发率分别为术后 1、2、3 年的 28.8%（64/222）、42.3%（94/222）和 47.7%（106/222）。多变量逻辑回归分析显示，肿瘤直径≥5cm[比值比（OR）=2.31，95%置信区间（CI）=1.27-4.17]、肝硬化（OR=2.11，95%CI=1.18-3.79）和术前天门冬氨酸氨基转移酶水平≥34IU/L（OR=2.02，95%CI=1.01-4.04）是 HCC 复发的独立危险因素。
肿瘤直径较大、肝硬化和术前天门冬氨酸氨基转移酶水平较高的患者术后 HCC 复发风险较高，应密切随访。
Zotero 插件