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肝细胞癌切除策略的最新进展:一篇叙述性综述

Update on Resection Strategies for Hepatocellular Carcinoma: A Narrative Review.

作者信息

Lee Jun Suh, Choi Hyeong Woo, Kim Ji Su, Lee Tae Yoon, Yoon Young Chul

机构信息

Department of Surgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.

出版信息

Cancers (Basel). 2024 Dec 6;16(23):4093. doi: 10.3390/cancers16234093.

DOI:10.3390/cancers16234093
PMID:39682279
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11640626/
Abstract

Hepatocellular carcinoma (HCC) is the most common primary liver cancer, the incidence of which is rising globally. Despite recent advancements in immunotherapeutic and surgical treatment modalities, the prognosis for HCC remains poor. The surgical treatment strategy for HCC comprises a multimodal effort that ranges from ablative therapy and surgical resection to liver transplantation. Thanks to collective efforts from the surgical society, there have been rapid advances in resection strategies, such as 3D printing for surgical planning and minimally invasive techniques to minimize surgical trauma. This review examines recent advancements in surgical techniques, patient selection criteria, and perioperative management for HCC resection. The purpose of this review was to provide clinicians and researchers with an up-to-date perspective on the evolving role of surgical resection in HCC treatment, and to identify key areas for future investigation to improve patient outcomes.

摘要

肝细胞癌(HCC)是最常见的原发性肝癌,其全球发病率正在上升。尽管免疫治疗和手术治疗方式最近取得了进展,但HCC的预后仍然很差。HCC的手术治疗策略包括从消融治疗、手术切除到肝移植的多模式努力。由于外科学会的共同努力,切除策略取得了快速进展,如用于手术规划的3D打印和将手术创伤降至最低的微创技术。本综述探讨了HCC切除手术技术、患者选择标准和围手术期管理的最新进展。本综述的目的是为临床医生和研究人员提供关于手术切除在HCC治疗中不断演变的作用的最新观点,并确定未来研究的关键领域以改善患者预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d91/11640626/37494782e060/cancers-16-04093-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d91/11640626/37494782e060/cancers-16-04093-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d91/11640626/37494782e060/cancers-16-04093-g001.jpg

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本文引用的文献

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Current status of preoperative risk assessment for posthepatectomy liver failure in patients with hepatocellular carcinoma.肝细胞癌患者肝切除术后肝衰竭术前风险评估的现状
Ann Gastroenterol Surg. 2023 May 21;7(6):871-886. doi: 10.1002/ags3.12692. eCollection 2023 Nov.
2
Is hepatectomy feasible for hepatocellular carcinoma patients with clinically significant portal hypertension and beyond the Milan criteria?对于合并有临床显著门静脉高压且超出米兰标准的肝细胞癌患者,肝切除术是否可行?
Eur J Surg Oncol. 2023 Nov;49(11):107073. doi: 10.1016/j.ejso.2023.107073. Epub 2023 Sep 21.
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Effect of anatomical liver resection for hepatocellular carcinoma: a systematic review and meta-analysis.
解剖性肝切除术治疗肝细胞癌的效果:系统评价和荟萃分析。
Int J Surg. 2023 Sep 1;109(9):2784-2793. doi: 10.1097/JS9.0000000000000503.
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Clinical Practice Guidelines for Hepatocellular Carcinoma: The Japan Society of Hepatology 2021 version (5th JSH-HCC Guidelines).肝细胞癌临床实践指南:日本肝脏学会2021版(第5版JSH-HCC指南)
Hepatol Res. 2023 May;53(5):383-390. doi: 10.1111/hepr.13892. Epub 2023 Mar 10.
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Global Epidemiology and Genetics of Hepatocellular Carcinoma.全球肝细胞癌的流行病学和遗传学
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Liver resection for hepatocellular carcinoma beyond the BCLC: are multinodular disease, portal hypertension, and portal system invasion real contraindications?超出巴塞罗那临床肝癌分期(BCLC)标准的肝细胞癌肝切除术:多结节病变、门静脉高压和门静脉系统侵犯真的是禁忌证吗?
J Gastrointest Oncol. 2022 Dec;13(6):3123-3134. doi: 10.21037/jgo-22-833.
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Laparoscopic versus open liver resection for hepatocellular carcinoma in elderly patients: Systematic review and meta-analysis of propensity-score matched studies.腹腔镜与开腹肝切除术治疗老年肝细胞癌的系统评价和倾向评分匹配研究的荟萃分析。
Int J Surg. 2022 Sep;105:106821. doi: 10.1016/j.ijsu.2022.106821. Epub 2022 Aug 7.
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