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本文引用的文献

1
Umbilical cord blood cell-derived neurospheres differentiate into Schwann-like cells.脐带血细胞来源的神经球分化为雪旺氏样细胞。
Neuroreport. 2009 Mar 4;20(4):354-9. doi: 10.1097/WNR.0b013e328323d74c.
2
Temporal changes in the level of neurotrophins in the spinal cord and associated precentral gyrus following spinal hemisection in adult Rhesus monkeys.成年恒河猴脊髓半横断后脊髓及相关中央前回中神经营养因子水平的时间变化。
J Chem Neuroanat. 2008 Dec;36(3-4):138-43. doi: 10.1016/j.jchemneu.2008.07.004. Epub 2008 Jul 22.
3
Gene expression alterations of neurotrophins, their receptors and prohormone convertases in a rat model of spinal cord contusion.脊髓挫伤大鼠模型中神经营养因子、其受体及激素原转化酶的基因表达改变
Neurosci Lett. 2008 Aug 29;441(3):261-6. doi: 10.1016/j.neulet.2008.06.046. Epub 2008 Jun 21.
4
Temporal changes in the expression of some neurotrophins in spinal cord transected adult rats.成年大鼠脊髓横断后某些神经营养因子表达的时间变化
Neuropeptides. 2007 Jun;41(3):135-43. doi: 10.1016/j.npep.2007.02.001. Epub 2007 Apr 24.
5
Expression of some neurotrophins in the spinal motoneurons after cord hemisection in adult rats.成年大鼠脊髓半横断后脊髓运动神经元中某些神经营养因子的表达
Neurosci Lett. 2006 Dec 27;410(3):222-7. doi: 10.1016/j.neulet.2006.10.006. Epub 2006 Oct 18.
6
Immunohistochemical distribution of NGF, BDNF, NT-3, and NT-4 in adult rhesus monkey brains.成年恒河猴大脑中神经生长因子（NGF）、脑源性神经营养因子（BDNF）、神经营养因子-3（NT-3）和神经营养因子-4（NT-4）的免疫组织化学分布
J Histochem Cytochem. 2007 Jan;55(1):1-19. doi: 10.1369/jhc.6A6952.2006. Epub 2006 Aug 9.
7
Deafferentation and neurotrophin-mediated intraspinal sprouting: a central role for the p75 neurotrophin receptor.去传入神经支配与神经营养因子介导的脊髓内轴突发芽：p75神经营养因子受体的核心作用。
Eur J Neurosci. 2005 Jan;21(1):81-92. doi: 10.1111/j.1460-9568.2004.03838.x.
8
Neurotrophic factors expressed in both cortex and spinal cord induce axonal plasticity after spinal cord injury.在皮层和脊髓中表达的神经营养因子可诱导脊髓损伤后轴突可塑性。
J Neurosci Res. 2003 Oct 15;74(2):221-6. doi: 10.1002/jnr.10718.
9
Neurotrophic factors and axonal growth.神经营养因子与轴突生长
Curr Opin Neurobiol. 2002 Oct;12(5):523-31. doi: 10.1016/s0959-4388(02)00372-0.
10
Accumulation of nerve growth factor protein at both rostral and caudal stumps in the transected rat spinal cord.在横断的大鼠脊髓中，神经生长因子蛋白在头端和尾端残端均有积累。
J Neurol Sci. 2002 Jun 15;198(1-2):63-9. doi: 10.1016/s0022-510x(02)00080-1.

成年大鼠脊髓和大脑皮层横断后酪氨酸激酶受体 C 的表达。

Expression of tyrosine kinase receptor C in the segments of the spinal cord and the cerebral cortex after cord transection in adult rats.

机构信息

Department of Neurosurgery, the Third Affiliated Hospital, Guangzhou Medical College, Guangzhou 510150, China.

出版信息

Neurosci Bull. 2011 Apr;27(2):83-90. doi: 10.1007/s12264-011-1150-1.

DOI:10.1007/s12264-011-1150-1
PMID:21441969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5560345/
Abstract

OBJECTIVE

To investigate the role of tyrosine kinase receptor C (TrkC), the receptor of neurotrophin-3 (NT-3), in neuroplasticity following spinal cord injury (SCI).

METHODS

Rats with cord transection were allowed to survive for 1, 3, 7 and 14 d post operation (dpo). TrkC expressions at lower thoracic levels of the spinal cord and in precentral gyrus of cerebral cortex were investigated.

RESULTS

TrkC protein levels at both the site of injury (T10-T11) and the neighboring segments (T9 and T12) in the spinal cord decreased significantly at 1-7 dpo, followed by a rapid increase at 14 dpo. The temporal changes in TrkC mRNA expression level showed a similar pattern with that of TrkC protein. In addition, the levels of TrkC protein and mRNA at the site of injury (T10-T11) were significantly higher than those at the neighboring spinal segments (T9 and T12). Besides, the levels of TrkC protein and mRNA were higher at the rostral segment than at the caudal segment. However, in the motor cortex, TrkC protein was not detected and TrkC mRNA was expressed at a very low level.

CONCLUSION

These results suggest that TrkC may be involved in neuroplasticity after SCI.

摘要

目的

探讨神经营养因子-3（NT-3）的受体酪氨酸激酶受体 C（TrkC）在脊髓损伤（SCI）后神经重塑中的作用。

方法

对脊髓横断大鼠进行术后 1、3、7 和 14 d 的生存实验，观察脊髓下胸段和大脑皮质运动前区的 TrkC 表达情况。

结果

伤段（T10-T11）及相邻节段（T9 和 T12）脊髓内 TrkC 蛋白水平在术后 1-7 d 显著下降，随后在 14 d 迅速增加。TrkC mRNA 表达水平的时间变化与 TrkC 蛋白相似。此外，伤段（T10-T11）的 TrkC 蛋白和 mRNA 水平明显高于相邻脊髓节段（T9 和 T12）。此外，TrkC 蛋白和 mRNA 的水平在脊髓上段比下段高。然而，在运动皮质中，未检测到 TrkC 蛋白，TrkC mRNA 的表达水平非常低。

结论

这些结果提示 TrkC 可能参与了 SCI 后的神经重塑。