Smith P H, Bono A, Calais da Silva F, Debruyne F, Denis L, Robinson P, Sylvester R, Armitage T G
St. James's University Hospital, Leeds, UK.
Cancer. 1990 Sep 1;66(5 Suppl):1009-16. doi: 10.1002/cncr.1990.66.s5.1009.
This article reviews the serial bone scans of 149 of 327 patients entered into a randomized prospective trial comparing orchidectomy versus zoladex and flutamide in patients with metastatic prostatic cancer. Attention is drawn to the difficulty of evaluating the response rate and of the importance of tumor load in determining survival. The use of sequential bone scans once the diagnosis of metastatic disease has been confirmed is of questionable value as the scans are expensive and contribute little to the further management of the patient in the absence of symptoms requiring relief.
本文回顾了327例进入一项随机前瞻性试验的患者中149例的系列骨扫描结果，该试验比较了睾丸切除术与戈舍瑞林和氟他胺治疗转移性前列腺癌患者的疗效。文中指出了评估缓解率的困难以及肿瘤负荷在确定生存率方面的重要性。一旦确诊为转移性疾病，使用序贯骨扫描的价值存疑，因为扫描费用昂贵，而且在没有需要缓解的症状的情况下，对患者的进一步治疗帮助不大。
