Sutherland Owens Ashley N, Miguel Euripedes C, Swerdlow Neal R
Department of Psychiatry, UCSD School of Medicine, La Jolla, CA, USA.
ScientificWorldJournal. 2011 Mar 22;11:736-41. doi: 10.1100/tsw.2011.57.
Sensory and sensorimotor gating deficits characterize both Tourette syndrome (TS) and schizophrenia. Premonitory urges (PU) in TS can be assessed with the University of Sao Paulo Sensory Phenomena Scale (USP-SPS) and the Premonitory Urge for Tics Scale (PUTS). In 40 subjects (TS: n = 18; healthy comparison subjects [HCS]: n = 22), we examined the relationship between PU scores and measures of sensory gating using the USP-SPS, PUTS, Sensory Gating Inventory (SGI), and Structured Interview for Assessing Perceptual Anomalies (SIAPA), as well symptom severity scales. SGI, but not SIAPA, scores were elevated in TS subjects (p < 0.0003). In TS subjects, USP-SPS and PUTS scores correlated significantly with each other, but not with the SGI or SIAPA; neither PU nor sensory gating scales correlated significantly with symptom severity. TS subjects endorse difficulties in sensory gating and the SGI may be valuable for studying these clinical phenomena.
感觉和感觉运动门控缺陷是抽动秽语综合征（TS）和精神分裂症的共同特征。TS中的先兆冲动（PU）可以通过圣保罗大学感觉现象量表（USP-SPS）和抽动先兆冲动量表（PUTS）进行评估。在40名受试者中（TS：n = 18；健康对照受试者[HCS]：n = 22），我们使用USP-SPS、PUTS、感觉门控量表（SGI）和评估感知异常的结构化访谈（SIAPA）以及症状严重程度量表，研究了PU评分与感觉门控测量之间的关系。TS受试者的SGI评分升高，但SIAPA评分未升高（p < 0.0003）。在TS受试者中，USP-SPS和PUTS评分彼此显著相关，但与SGI或SIAPA无关；PU和感觉门控量表均与症状严重程度无显著相关性。TS受试者存在感觉门控困难，SGI可能对研究这些临床现象有价值。
