Zhou Jian, Ju Wei-Qiang, He Xiao-Shun, Wang Dong-Ping, Zhu Xiao-Feng, Wu Lin-Wei, Tai Qiang, Ma Yi, Hu An-Bin, Wang Guo-Dong, Huang Jie-Fu
Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2011 Mar;14(3):199-201.
To investigate the effect of Campath-1H induction on immunosuppression in small intestine transplantation.
Clinical data of a patient who underwent small intestine transplantation were retrospectively summarized.
Intraoperative Campath-1H induction by intravenous injection was administered. Triple immunosuppression(FK506, MMF and methylprednisolone) was used postoperatively. The lymphocyte and leukocyte decreased significantly following Campath-1H induction, and returned to normal after adjusting the dose of immunosuppressant and use of colony stimulating factor. There were no acute rejection, graft versus host disease, or severe infection during the immediate postoperative period. The patient recovered and discharged.
Intraoperative Campath-1H induction and postoperative triple immunosuppression using FK506, MMF, and methylprednisolone may prevent rejection and graft versus host disease in the early stage after small intestine transplantation.
探讨Campath-1H诱导对小肠移植免疫抑制的影响。
回顾性总结1例接受小肠移植患者的临床资料。
术中静脉注射进行Campath-1H诱导。术后采用三联免疫抑制方案（FK506、霉酚酸酯和甲泼尼龙）。Campath-1H诱导后淋巴细胞和白细胞显著减少，调整免疫抑制剂剂量并使用集落刺激因子后恢复正常。术后早期无急性排斥反应、移植物抗宿主病或严重感染。患者康复出院。
术中Campath-1H诱导及术后使用FK506、霉酚酸酯和甲泼尼龙进行三联免疫抑制可预防小肠移植术后早期的排斥反应和移植物抗宿主病。
