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[农业中化学物质暴露的风险评估与风险管理]

[Risk assessment and risk management of chemical exposures in agriculture].

作者信息

Moretto A

机构信息

Dipartimento di Medicina del Lavoro, Università degli Studi di Milano, Centro Internazionale per gli Antiparassitari e la Prevenzione Sanitaria (ICPS), Azienda Ospedaliera Luigi Sacco, Milano, Italy.

出版信息

G Ital Med Lav Ergon. 2010 Oct-Dec;32(4 Suppl):400-3.

Abstract

The most important risk in agriculture derives from exposure to pesticides. Pesticide risk assessment is conducted before (pre-market) and after (post-market) the introduction in use of the substance. Evaluation of the extensive toxicological studies required for all pesticides leads to the definition of the Acceptable Operator Exposure Level (AOEL) expressed as systemic dose (mg/kg). The AOEL is compared with exposures estimated by exposure models, that are currently being revised in the European Union. Only if estimated exposure is below the AOEL the product is authorised, sometimes with compulsory use of certain personal protective equipment. These are reported in the label. Post-marketing activities include health surveillance, biological monitoring, exposure monitoring, enforcement on the use of proper and properly maintained equipment, and use of proper personal protection devices.

摘要

农业中最重要的风险源自接触农药。农药风险评估在该物质投入使用之前(上市前)和之后(上市后)进行。对所有农药所需的广泛毒理学研究进行评估,得出以全身剂量(毫克/千克)表示的可接受操作人员接触水平(AOEL)。AOEL与接触模型估计的接触量进行比较,目前欧盟正在对这些模型进行修订。只有当估计接触量低于AOEL时,该产品才会被批准,有时还会强制要求使用某些个人防护设备。这些会在标签中注明。上市后活动包括健康监测、生物监测、接触监测、对正确使用和妥善维护设备的执法,以及使用适当的个人防护装置。

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