Bregestovski P D
Biofizika. 2011 Jan-Feb;56(1):62-73.
Ion channels of biological membranes are the key proteins, which provide bioelectric functioning of living systems. These proteins are homo- or heterooligomers assembled from several identical or different subunits. Understanding the architectural organization and functioning of ion channels has been significantly extended due to resolving the crystal structure of several types of voltage-gated and receptor-operated channels. This review summarizes the information obtained from crystal structures of potassium, nicotinic acetylcholine receptor, P2X, and other ligand-gated ion channels. Despite the differences in the function, topology, ionic selectivity, and the subunit stoichiometry, a high similarity in the principles of organization of these macromolecular complexes has been revealed.
生物膜离子通道是关键蛋白质，它们为生命系统提供生物电功能。这些蛋白质是由几个相同或不同亚基组装而成的同聚体或异聚体。由于解析了几种类型的电压门控通道和受体操纵通道的晶体结构，对离子通道的结构组织和功能的理解有了显著扩展。本综述总结了从钾离子通道、烟碱型乙酰胆碱受体、P2X和其他配体门控离子通道的晶体结构中获得的信息。尽管在功能、拓扑结构、离子选择性和亚基化学计量方面存在差异，但已揭示出这些大分子复合物在组织原则上具有高度相似性。
