Shkliar T F, Toropova O A, Safronov A P, Pollack G H, Bliakhman F A
Biofizika. 2011 Jan-Feb;56(1):78-84.
A physical model of the cytoskeleton based on synthetic polyelectrolyte hydrogel of polymethacrylic acid has been proposed. From the physicochemical point of view, the structures of polyelectrolyte gel and the cytoskeleton show a high degree of similarity. It was shown that polyelectrolyte gel can shorten and produce mechanical stress in response to changes in the composition of the surrounding solution. The mechanical properties of the model gel were evaluated: Young modulus (2-6 kPa), stress relaxation time (0.1-1 s), and apparent viscosity (0.3-3 kPa x s). The viscoelastic properties of the gel depend on the degree of its swelling. It has been demonstrated that the mechanical properties of gels of polymethacrylic acid are close to those of biological objects.
提出了一种基于聚甲基丙烯酸合成聚电解质水凝胶的细胞骨架物理模型。从物理化学角度来看，聚电解质凝胶和细胞骨架的结构具有高度相似性。结果表明，聚电解质凝胶可根据周围溶液成分的变化而缩短并产生机械应力。对模型凝胶的力学性能进行了评估：杨氏模量（2 - 6千帕）、应力松弛时间（0.1 - 1秒）和表观粘度（0.3 - 3千帕·秒）。凝胶的粘弹性取决于其溶胀程度。已经证明，聚甲基丙烯酸凝胶的力学性能与生物物体的力学性能相近。
