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脂肪来源干细胞通过SDF-1/CXCR4轴促进胃癌细胞的生长、迁移和侵袭。

Adipose-derived stem cells promote gastric cancer cell growth, migration and invasion through SDF-1/CXCR4 axis.

作者信息

Zhao Bao-Cheng, Zhao Bo, Han Jia-Gang, Ma Hua-Chong, Wang Zhen-Jun

机构信息

Department of General Surgery, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Lu, Chaoyang District, Beijing 100020, PR China.

出版信息

Hepatogastroenterology. 2010 Nov-Dec;57(104):1382-9.

PMID:21443090
Abstract

BACKGROUND/AIMS: The CXCR4/SDF-1 axis regulates the trafficking of various cell types. In the study we investigated whether adipose-derived stem cells can promote gastric cancer cell growth and migration through SDF-1/CXCR4 axis.

METHODOLOGY

The expression of CXCR4 in gastric cancer cell line MGC-803 and SDF-1 in Adipose-derived stem cells was detected by using PCR method. Furthermore, cell proliferation, migration and invasion assays were examined and inhibitors of CXCR4 were used to determine the effect on cell migration.

RESULTS

The cells isolated from subcutaneous adipose tissue show characteristics of stem cells. Gastric cancer cells express CXCR4 and Adipose-derived stem cells express SDF-1. Additionally, the tumor cells showed vigorous proliferative and migratory responses to ADSCs. AMD3100 can effectively reduce the migration of gastric cancer cells.

CONCLUSIONS

Adipose-derived stem cells can promote gastric cancer cell growth, migration and invasion through SDF-1/CXCR4 axis. CXCR4 can be used in the treatment of gastric cancer as a potential therapeutic target.

摘要

背景/目的：CXCR4/SDF-1轴调节多种细胞类型的迁移。在本研究中，我们调查了脂肪来源干细胞是否能通过SDF-1/CXCR4轴促进胃癌细胞的生长和迁移。

方法

采用PCR方法检测胃癌细胞系MGC-803中CXCR4的表达以及脂肪来源干细胞中SDF-1的表达。此外，检测细胞增殖、迁移和侵袭试验，并使用CXCR4抑制剂来确定对细胞迁移的影响。

结果

从皮下脂肪组织分离的细胞表现出干细胞的特征。胃癌细胞表达CXCR4，脂肪来源干细胞表达SDF-1。此外，肿瘤细胞对脂肪来源干细胞表现出强烈的增殖和迁移反应。AMD3100可有效降低胃癌细胞的迁移。

结论

脂肪来源干细胞可通过SDF-1/CXCR4轴促进胃癌细胞的生长、迁移和侵袭。CXCR4可作为潜在治疗靶点用于胃癌治疗。

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