Chung Hye Won, Lim Jong-Baeck
Hye Won Chung, Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 135-720, South Korea.
World J Gastroenterol. 2014 Feb 21;20(7):1667-80. doi: 10.3748/wjg.v20.i7.1667.
Gastric carcinoma (GC) is the 4(th) most prevalent cancer and has the 2(nd) highest cancer-related mortality rate worldwide. Despite the incidence of GC has decreased over the past few decades, it is still a serious health problem. Chronic inflammatory status of the stomach, caused by the infection of Helicobacter pylori (H. pylori) and through the production of inflammatory mediators within the parenchyma is suspected to play an important role in the initiation and progression of GC. In this review, the correlation between chronic inflammation and H. pylori infection as an important factor for the development of GC will be discussed. Major components, including tumor-associated macrophages, lymphocytes, cancer-associated fibroblasts, angiogenic factors, cytokines, and chemokines of GC microenvironment and their mechanism of action on signaling pathways will also be discussed. Increasing our understanding of how the components of the tumor microenvironment interact with GC cells and the signaling pathways involved could help identify new therapeutic and chemopreventive targets.
胃癌（GC）是全球第四大常见癌症，癌症相关死亡率位居第二。尽管在过去几十年里胃癌发病率有所下降，但它仍是一个严重的健康问题。由幽门螺杆菌（H. pylori）感染以及实质内炎症介质的产生所导致的胃部慢性炎症状态，被怀疑在胃癌的发生和发展中起重要作用。在本综述中，将讨论慢性炎症与幽门螺杆菌感染之间的相关性，幽门螺杆菌感染是胃癌发生的一个重要因素。还将讨论胃癌微环境的主要成分，包括肿瘤相关巨噬细胞、淋巴细胞、癌症相关成纤维细胞、血管生成因子、细胞因子和趋化因子，以及它们对信号通路的作用机制。加深我们对肿瘤微环境成分如何与胃癌细胞相互作用以及所涉及的信号通路的理解，有助于确定新的治疗和化学预防靶点。
