Hashimoto Kazuo, Higaki Shingo, Nishiahi Makoto, Fujiwara Keiko, Gondo Toshikazu, Sakaida Isao
Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Japan.
Hepatogastroenterology. 2010 Nov-Dec;57(104):1399-404.
BACKGROUND/AIMS: It is not clear whether chromoendoscopy with indigo carmine improves the rate of detection of colorectal polyps compared to: detection via standard colonoscopy. The aim of our study was to determine whether chromoendoscopy with indigo carmine significantly improves the detection of adenomas in the distal colon and rectum.
Using back-to-back sigmoidoscopies in each study patient, we prospectively evaluated whether chromoendoscopy with indigo carmine picked up more adenomatous polyps than standard colonoscopy. In all patients, standard high-resolution complete colonoscopy without indigo carmine was performed at the first examination. The second examination was restricted to colonoscopy distal to the splenic flexure of the colon. For the second examination, patients were randomized to chromoendoscopy with indigo carmine or colonoscopy without indigo carmine application. The second examination's detection rate was compared between the two groups.
In the 60 patients in the chromoendoscopy with indigo carmine group, 38 adenomas were found in the first examination and 14 adenomas in the second examination. In the 70 patients in the standard colonoscopy group, 66 adenomas were found in the first examination and 32 adenomas in the second examination. The detection rates in the two groups were 26.9% and 32.7%, re spectively, which were not significantly different (p = 0.47).
Chromoendoscopy did not detect more adenomatous polyps in comparison to standard colonoscopy.
背景/目的：与通过标准结肠镜检查进行检测相比，使用靛胭脂进行染色内镜检查是否能提高大肠息肉的检出率尚不清楚。我们研究的目的是确定使用靛胭脂进行染色内镜检查是否能显著提高远端结肠和直肠腺瘤的检出率。
在每位研究患者中使用背靠背乙状结肠镜检查，我们前瞻性评估了使用靛胭脂进行染色内镜检查是否比标准结肠镜检查能发现更多腺瘤性息肉。在所有患者中，首次检查时进行不使用靛胭脂的标准高分辨率全结肠镜检查。第二次检查仅限于结肠脾曲远端的结肠镜检查。对于第二次检查，患者被随机分为使用靛胭脂进行染色内镜检查组或不使用靛胭脂进行结肠镜检查组。比较两组第二次检查的检出率。
在使用靛胭脂进行染色内镜检查组的60例患者中，首次检查发现38个腺瘤，第二次检查发现14个腺瘤。在标准结肠镜检查组的70例患者中，首次检查发现66个腺瘤，第二次检查发现32个腺瘤。两组的检出率分别为26.9%和32.7%，差异无统计学意义（p = 0.47）。
与标准结肠镜检查相比，染色内镜检查未发现更多腺瘤性息肉。
